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Showing CypComp Card for CC00016: Midazolam (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:15:50 UTC
Last Updated2019-10-01 21:37:08 UTC
CypComp IDCC00016
Compound Information
NameMidazolam
Structure ImageDdligbofavuzhb uhfffaoysa n
InChIKeyDDLIGBOFAVUZHB-UHFFFAOYSA-N
PubChem ID4192
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantReactant
References
  1. Khan KK, He YQ, Domanski TL, Halpert JR: Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation. Mol Pharmacol. 2002 Mar;61(3):495-506. doi: 10.1124/mol.61.3.495. [PubMed:11854429 ]
  2. Ekins S, Vandenbranden M, Ring BJ, Gillespie JS, Yang TJ, Gelboin HV, Wrighton SA: Further characterization of the expression in liver and catalytic activity of CYP2B6. J Pharmacol Exp Ther. 1998 Sep;286(3):1253-9. [PubMed:9732386 ]
Download FileCC00016.sdf