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Showing CypComp Card for CC00031: Zafirlukast (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:16:00 UTC
Last Updated2019-10-01 21:37:09 UTC
CypComp IDCC00031
Compound Information
NameZafirlukast
Structure ImageYeezwchgznkeek uhfffaoysa n
InChIKeyYEEZWCHGZNKEEK-UHFFFAOYSA-N
PubChem ID5717
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantReactant
References
  1. Kassahun K, Skordos K, McIntosh I, Slaughter D, Doss GA, Baillie TA, Yost GS: Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme. Chem Res Toxicol. 2005 Sep;18(9):1427-37. doi: 10.1021/tx050092b. [PubMed:16167835 ]
Download FileCC00031.sdf