Showing CypComp Card for CC00032: Tolbutamide (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:16:01 UTC
Last Updated2019-10-01 21:37:10 UTC
CypComp IDCC00032
Compound Information
NameTolbutamide
Structure ImageJlrgjrbpoggcbt uhfffaoysa n
InChIKeyJLRGJRBPOGGCBT-UHFFFAOYSA-N
PubChem ID5505
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantReactantReactantReactantNon-ReactantNon-ReactantNon-Reactant
References
  1. Komatsu K, Ito K, Nakajima Y, Kanamitsu Si, Imaoka S, Funae Y, Green CE, Tyson CA, Shimada N, Sugiyama Y: Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments. Drug Metab Dispos. 2000 Apr;28(4):475-81. [PubMed:10725317 ]
  2. Veronese ME, Mackenzie PI, Doecke CJ, McManus ME, Miners JO, Birkett DJ: Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9. Biochem Biophys Res Commun. 1991 Mar 29;175(3):1112-8. doi: 10.1016/0006-291x(91)91680-b. [PubMed:2025243 ]
  3. Wester MR, Lasker JM, Johnson EF, Raucy JL: CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes. Drug Metab Dispos. 2000 Mar;28(3):354-9. [PubMed:10681382 ]
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