Record Information
Version1.0
Creation Date2019-07-14 16:16:49 UTC
Last Updated2019-10-01 21:37:18 UTC
CypComp IDCC00098
Compound Information
NameTroglitazone
Structure ImageGxphkuhsujuwkp cyfredjksa n
InChIKeyGXPHKUHSUJUWKP-CYFREDJKSA-N
PubChem ID6518172
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
ReactantNon-ReactantReactantReactantNon-ReactantReactantReactantReactantReactant
References
  1. Yamazaki H, Shibata A, Suzuki M, Nakajima M, Shimada N, Guengerich FP, Yokoi T: Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metab Dispos. 1999 Nov;27(11):1260-6. [PubMed:10534310 ]
  2. He K, Talaat RE, Woolf TF: Incorporation of an oxygen from water into troglitazone quinone by cytochrome P450 and myeloperoxidase. Drug Metab Dispos. 2004 Apr;32(4):442-6. doi: 10.1124/dmd.32.4.442. [PubMed:15039298 ]
  3. He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF: Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved. Drug Metab Dispos. 2004 Jun;32(6):639-46. doi: 10.1124/dmd.32.6.639. [PubMed:15155556 ]
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