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Showing CypComp Card for CC00106: Methadone (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:16:55 UTC
Last Updated2019-10-01 21:37:19 UTC
CypComp IDCC00106
Compound Information
NameMethadone
Structure ImageUssiqxcvuwkgnf qgzvfwflsa n
InChIKeyUSSIQXCVUWKGNF-QGZVFWFLSA-N
PubChem ID22267
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantReactantReactantNon-ReactantReactantReactantNon-ReactantReactant
References
  1. Gerber JG, Rhodes RJ, Gal J: Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19. Chirality. 2004 Jan;16(1):36-44. doi: 10.1002/chir.10303. [PubMed:14628297 ]
  2. Iribarne C, Berthou F, Baird S, Dreano Y, Picart D, Bail JP, Beaune P, Menez JF: Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem Res Toxicol. 1996 Mar;9(2):365-73. doi: 10.1021/tx950116m. [PubMed:8839037 ]
Download FileCC00106.sdf