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Showing CypComp Card for CC00165: Simvastatin hydroxy acid (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:17:40 UTC
Last Updated2019-10-01 21:37:27 UTC
CypComp IDCC00165
Compound Information
NameSimvastatin hydroxy acid
Structure ImageXwlxkknpfmnsfa srirljbesa n
InChIKeyXWLXKKNPFMNSFA-SRIRLJBESA-N
PubChem ID93476683
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantReactant
References
  1. Prueksaritanont T, Ma B, Yu N: The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6. Br J Clin Pharmacol. 2003 Jul;56(1):120-4. doi: 10.1046/j.1365-2125.2003.01833.x. [PubMed:12848784 ]
  2. Prueksaritanont T, Gorham LM, Ma B, Liu L, Yu X, Zhao JJ, Slaughter DE, Arison BH, Vyas KP: In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s. Drug Metab Dispos. 1997 Oct;25(10):1191-9. [PubMed:9321523 ]
Download FileCC00165.sdf