Showing CypComp Card for CC00191: Sertraline (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:17:59 UTC
Last Updated2019-10-01 21:37:29 UTC
CypComp IDCC00191
Compound Information
NameSertraline
Structure ImageVgkdlmbjgbxtgi sjcjkpomsa n
InChIKeyVGKDLMBJGBXTGI-SJCJKPOMSA-N
PubChem ID68617
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
ReactantReactantReactantReactantReactantReactantReactantReactantReactant
References
  1. Obach RS, Cox LM, Tremaine LM: Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. doi: 10.1124/dmd.104.002428. Epub 2004 Nov 16. [PubMed:15547048 ]
  2. Kobayashi K, Ishizuka T, Shimada N, Yoshimura Y, Kamijima K, Chiba K: Sertraline N-demethylation is catalyzed by multiple isoforms of human cytochrome P-450 in vitro. Drug Metab Dispos. 1999 Jul;27(7):763-6. [PubMed:10383917 ]
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