Showing CypComp Card for CC00192: Nortriptyline (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:18:00 UTC
Last Updated2019-10-01 21:37:29 UTC
CypComp IDCC00192
Compound Information
NameNortriptyline
Structure ImagePhvgltmqbufiqq uhfffaoysa n
InChIKeyPHVGLTMQBUFIQQ-UHFFFAOYSA-N
PubChem ID4543
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantReactantReactantNon-ReactantReactant
References
  1. Breyer-Pfaff U: The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man. Drug Metab Rev. 2004 Oct;36(3-4):723-46. doi: 10.1081/DMR-200033482. [PubMed:15554244 ]
  2. Venkatakrishnan K, von Moltke LL, Greenblatt DJ: Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs. J Clin Pharmacol. 1999 Jun;39(6):567-77. [PubMed:10354960 ]
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