Showing CypComp Card for CC00215: Voriconazole (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:18:14 UTC
Last Updated2019-10-01 21:37:32 UTC
CypComp IDCC00215
Compound Information
NameVoriconazole
Structure ImageBcehbskcwlpmdn mgplvramsa n
InChIKeyBCEHBSKCWLPMDN-MGPLVRAMSA-N
PubChem ID71616
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantNon-ReactantReactantReactantNon-ReactantNon-ReactantReactant
References
  1. Hyland R, Jones BC, Smith DA: Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole. Drug Metab Dispos. 2003 May;31(5):540-7. doi: 10.1124/dmd.31.5.540. [PubMed:12695341 ]
  2. Murayama N, Imai N, Nakane T, Shimizu M, Yamazaki H: Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. Biochem Pharmacol. 2007 Jun 15;73(12):2020-6. doi: 10.1016/j.bcp.2007.03.012. Epub 2007 Mar 19. [PubMed:17433262 ]
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