Showing CypComp Card for CC00289: BMS-275183 (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:19:06 UTC
Last Updated2019-10-01 21:37:41 UTC
CypComp IDCC00289
Compound Information
NameBMS-275183
Structure ImageAhxichppxigcbn tyvwmptdsa n
InChIKeyAHXICHPPXIGCBN-TYVWMPTDSA-N
PubChem IDNot Available
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantReactant
References
  1. Zhang D, Ly VT, Lago M, Tian Y, Gan J, Humphreys WG, Comezoglu SN: CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4- O-methoxycarbonyl-paclitaxel (BMS-275183). Drug Metab Dispos. 2009 Apr;37(4):710-8. doi: 10.1124/dmd.108.024398. Epub 2009 Jan 21. [PubMed:19158314 ]
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