Showing CypComp Card for CC00391: 4-Hydroxytamoxifen (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:20:18 UTC
Last Updated2019-10-01 21:37:53 UTC
CypComp IDCC00391
Compound Information
Name4-Hydroxytamoxifen
Structure ImageTxuzvzsfrxzgtl qplcgjkrsa n
InChIKeyTXUZVZSFRXZGTL-QPLCGJKRSA-N
PubChem ID449459
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantReactant
References
  1. Dehal SS, Kupfer D: Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. Drug Metab Dispos. 1999 Jun;27(6):681-8. [PubMed:10348797 ]
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