Showing CypComp Card for CC00400: Bosentan (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:20:24 UTC
Last Updated2019-10-01 21:37:54 UTC
CypComp IDCC00400
Compound Information
NameBosentan
Structure ImageGjpicjjjrgtnod uhfffaoysa n
InChIKeyGJPICJJJRGTNOD-UHFFFAOYSA-N
PubChem ID104865
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantNon-ReactantReactantNon-ReactantNon-ReactantNon-ReactantReactant
References
  1. van Giersbergen PL, Treiber A, Clozel M, Bodin F, Dingemanse J: In vivo and in vitro studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide. Clin Pharmacol Ther. 2002 Apr;71(4):253-62. doi: 10.1067/mcp.2002.122473. [PubMed:11956508 ]
  2. van Giersbergen PL, Popescu G, Bodin F, Dingemanse J: Influence of mild liver impairment on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. J Clin Pharmacol. 2003 Jan;43(1):15-22. [PubMed:12520623 ]
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