Record Information
Version1.0
Creation Date2019-07-14 16:20:37 UTC
Last Updated2019-10-01 21:37:56 UTC
CypComp IDCC00418
Compound Information
NameSibutramine
Structure ImageUnaanxdkbxwmln inizcteosa n
InChIKeyUNAANXDKBXWMLN-INIZCTEOSA-N
PubChem ID937011
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantReactantNon-ReactantNon-ReactantReactantNon-ReactantNon-ReactantReactant
References
  1. Bae SK, Cao S, Seo KA, Kim H, Kim MJ, Shon JH, Liu KH, Zhou HH, Shin JG: Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes. Drug Metab Dispos. 2008 Aug;36(8):1679-88. doi: 10.1124/dmd.108.020727. Epub 2008 May 12. [PubMed:18474675 ]
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