Showing CypComp Card for CC00428: Flunitrazepam (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:20:45 UTC
Last Updated2019-10-01 21:37:58 UTC
CypComp IDCC00428
Compound Information
NameFlunitrazepam
Structure ImagePptyjkaxvccbdu uhfffaoysa n
InChIKeyPPTYJKAXVCCBDU-UHFFFAOYSA-N
PubChem ID3380
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
ReactantReactantReactantReactantReactantReactantReactantNon-ReactantReactant
References
  1. Hesse LM, Venkatakrishnan K, von Moltke LL, Shader RI, Greenblatt DJ: CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001 Feb;29(2):133-40. [PubMed:11159802 ]
  2. Gafni I, Busto UE, Tyndale RF, Kaplan HL, Sellers EM: The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo. J Clin Psychopharmacol. 2003 Apr;23(2):169-75. [PubMed:12640218 ]
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