Showing CypComp Card for CC00451: Nicotine (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:21:01 UTC
Last Updated2019-10-01 21:38:01 UTC
CypComp IDCC00451
Compound Information
NameNicotine
Structure ImageSnicxcgakadscv jtqlqieisa n
InChIKeySNICXCGAKADSCV-JTQLQIEISA-N
PubChem ID89594
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
ReactantReactantReactantReactantReactantReactantReactantReactantReactant
References
  1. Yamazaki H, Inoue K, Hashimoto M, Shimada T: Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70. [PubMed:10350185 ]
  2. Hukkanen J, Jacob P 3rd, Benowitz NL: Metabolism and disposition kinetics of nicotine. Pharmacol Rev. 2005 Mar;57(1):79-115. doi: 10.1124/pr.57.1.3. [PubMed:15734728 ]
  3. Yamanaka H, Nakajima M, Fukami T, Sakai H, Nakamura A, Katoh M, Takamiya M, Aoki Y, Yokoi T: CYP2A6 AND CYP2B6 are involved in nornicotine formation from nicotine in humans: interindividual differences in these contributions. Drug Metab Dispos. 2005 Dec;33(12):1811-8. doi: 10.1124/dmd.105.006254. Epub 2005 Aug 31. [PubMed:16135656 ]
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