Record Information
Version1.0
Creation Date2019-07-14 16:21:19 UTC
Last Updated2019-10-01 21:38:03 UTC
CypComp IDCC00477
Compound Information
NameClopidogrel
Structure ImageGktwggqpfaxnfi oahllokosa n
InChIKeyGKTWGGQPFAXNFI-OAHLLOKOSA-N
PubChem ID667556
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
ReactantNon-ReactantReactantReactantReactantReactantReactantNon-ReactantReactant
References
  1. Dansette PM, Libraire J, Bertho G, Mansuy D: Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel. Chem Res Toxicol. 2009 Feb;22(2):369-73. doi: 10.1021/tx8004828. [PubMed:19170597 ]
  2. Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A: Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos. 2010 Jan;38(1):92-9. doi: 10.1124/dmd.109.029132. [PubMed:19812348 ]
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