Showing CypComp Card for CC00480: Diltiazem (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:21:21 UTC
Last Updated2019-10-01 21:38:04 UTC
CypComp IDCC00480
Compound Information
NameDiltiazem
Structure ImageHsugrbwqsszjop rtwawaebsa n
InChIKeyHSUGRBWQSSZJOP-RTWAWAEBSA-N
PubChem ID39186
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantReactantReactantNon-ReactantReactantNon-ReactantReactant
References
  1. Sutton D, Butler AM, Nadin L, Murray M: Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. J Pharmacol Exp Ther. 1997 Jul;282(1):294-300. [PubMed:9223567 ]
  2. Molden E, Asberg A, Christensen H: CYP2D6 is involved in O-demethylation of diltiazem. An in vitro study with transfected human liver cells. Eur J Clin Pharmacol. 2000 Nov;56(8):575-9. [PubMed:11151747 ]
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