Showing CypComp Card for CC00506: 7-Methoxycoumarin (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:21:37 UTC
Last Updated2019-10-01 21:38:06 UTC
CypComp IDCC00506
Compound Information
Name7-Methoxycoumarin
Structure ImageLiialpbmiovahh uhfffaoysa n
InChIKeyLIIALPBMIOVAHH-UHFFFAOYSA-N
PubChem ID10748
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
ReactantReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantNon-Reactant
References
  1. Kim KH, Isin EM, Yun CH, Kim DH, Guengerich FP: Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation. FEBS J. 2006 May;273(10):2223-31. doi: 10.1111/j.1742-4658.2006.05235.x. [PubMed:16649998 ]
  2. Yun CH, Kim KH, Calcutt MW, Guengerich FP: Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6. J Biol Chem. 2005 Apr 1;280(13):12279-91. doi: 10.1074/jbc.M411019200. Epub 2005 Jan 22. [PubMed:15665333 ]
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