Showing CypComp Card for CC00515: Tienilic acid (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:21:43 UTC
Last Updated2019-10-01 21:38:08 UTC
CypComp IDCC00515
Compound Information
NameTienilic acid
Structure ImageAghanlsbxuwxtb uhfffaoysa n
InChIKeyAGHANLSBXUWXTB-UHFFFAOYSA-N
PubChem ID38409
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantReactantReactantNon-ReactantNon-ReactantNon-ReactantNon-Reactant
References
  1. Lopez Garcia MP, Dansette PM, Valadon P, Amar C, Beaune PH, Guengerich FP, Mansuy D: Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10. Eur J Biochem. 1993 Apr 1;213(1):223-32. doi: 10.1111/j.1432-1033.1993.tb17752.x. [PubMed:8477697 ]
  2. Jean P, Lopez-Garcia P, Dansette P, Mansuy D, Goldstein JL: Oxidation of tienilic acid by human yeast-expressed cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this drug is a mechanism-based inhibitor specific for cytochrome P-450 2C9. Eur J Biochem. 1996 Nov 1;241(3):797-804. doi: 10.1111/j.1432-1033.1996.00797.x. [PubMed:8944768 ]
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