Showing CypComp Card for CC00630: Quinine (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:23:03 UTC
Last Updated2019-10-01 21:38:21 UTC
CypComp IDCC00630
Compound Information
NameQuinine
Structure ImageLouprkontzgtke wzblmqshsa n
InChIKeyLOUPRKONTZGTKE-WZBLMQSHSA-N
PubChem ID3034034
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
Non-ReactantNon-ReactantNon-ReactantNon-ReactantNon-ReactantReactantNon-ReactantNon-ReactantReactant
References
  1. Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T: Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. J Pharmacol Exp Ther. 1996 Dec;279(3):1327-34. [PubMed:8968357 ]
  2. Mirghani RA, Yasar U, Zheng T, Cook JM, Gustafsson LL, Tybring G, Ericsson O: Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway. Drug Metab Dispos. 2002 Dec;30(12):1368-71. doi: 10.1124/dmd.30.12.1368. [PubMed:12433805 ]
Download FileCC00630.sdf