Showing CypComp Card for CC00679: Doxepin (CypReact Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:23:33 UTC
Last Updated2019-10-01 21:38:27 UTC
CypComp IDCC00679
Compound Information
NameDoxepin
Structure ImageOdqwqrrapptvag bopftxtbsa n
InChIKeyODQWQRRAPPTVAG-BOPFTXTBSA-N
PubChem ID667468
CypCompound Information
SetCypReact Training Set
Reactant Statuses
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
ReactantNon-ReactantNon-ReactantNon-ReactantReactantReactantReactantNon-ReactantReactant
References
  1. Hartter S, Tybring G, Friedberg T, Weigmann H, Hiemke C: The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res. 2002 Jul;19(7):1034-7. [PubMed:12180536 ]
  2. Haritos VS, Ghabrial H, Ahokas JT, Ching MS: Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin. Pharmacogenetics. 2000 Oct;10(7):591-603. [PubMed:11037801 ]
Download FileCC00679.sdf