Record Information |
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Version | 1.0 |
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Creation Date | 2019-07-14 16:35:07 UTC |
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Last Updated | 2019-10-01 21:40:52 UTC |
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CypComp ID | CC01829 |
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Compound Information |
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Name | 7-Methoxycoumarin |
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Structure Image | |
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InChIKey | LIIALPBMIOVAHH-UHFFFAOYSA-N |
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PubChem ID | 10748 |
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CypCompound Information |
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Set | CypBoM Training Set |
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Bonds of Metabolism (BoMs) | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 | - <11,H;Hydroxylation;R1>
- <13,H;Oxidation;R2>
- <13,2;Cleavage;R2>
| - <11,H;Hydroxylation;R1>
- <13,H;Oxidation;R2>
- <13,2;Cleavage;R2>
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References | - Kim KH, Isin EM, Yun CH, Kim DH, Guengerich FP: Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation. FEBS J. 2006 May;273(10):2223-31. doi: 10.1111/j.1742-4658.2006.05235.x. [PubMed:16649998 ]
- Yun CH, Kim KH, Calcutt MW, Guengerich FP: Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6. J Biol Chem. 2005 Apr 1;280(13):12279-91. doi: 10.1074/jbc.M411019200. Epub 2005 Jan 22. [PubMed:15665333 ]
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Download File | CC01829.sdf |
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