Showing CypComp Card for CC01877: Acetaminophen (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:25 UTC
Last Updated2019-10-01 21:40:57 UTC
CypComp IDCC01877
Compound Information
NameAcetaminophen
Structure ImageRzvajinkpmorjf uhfffaoysa n
InChIKeyRZVAJINKPMORJF-UHFFFAOYSA-N
PubChem ID1983
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <1,9;Oxidation;R1>
  • <9,8;Reduction;R1>
  • <8,6;Oxidation;R1>
  • <6,4;Reduction;R1>
  • <4,5;Reduction;R1>
  • <5,7;Oxidation;R1>
  • <7,9;Reduction;R1>
  • <3,4;Oxidation;R1>
  • <7,H;Hydroxylation;R1>
  • <8,H;Hydroxylation;R2>
  • <1,9;Oxidation;R3>
  • <9,8;Reduction;R3>
  • <8,6;Oxidation;R3>
  • <6,4;Reduction;R3>
  • <4,5;Reduction;R3>
  • <5,7;Oxidation;R3>
  • <7,9;Reduction;R3>
  • <3,4;Oxidation;R3>
  • Not Available
  • <1,9;Oxidation;R1>
  • <9,8;Reduction;R1>
  • <8,6;Oxidation;R1>
  • <6,4;Reduction;R1>
  • <4,5;Reduction;R1>
  • <5,7;Oxidation;R1>
  • <7,9;Reduction;R1>
  • <3,4;Oxidation;R1>
  • <1,9;Oxidation;R1>
  • <9,8;Reduction;R1>
  • <8,6;Oxidation;R1>
  • <6,4;Reduction;R1>
  • <4,5;Reduction;R1>
  • <5,7;Oxidation;R1>
  • <7,9;Reduction;R1>
  • <3,4;Oxidation;R1>
  • Not Available
  • <1,9;Oxidation;R1>
  • <9,8;Reduction;R1>
  • <8,6;Oxidation;R1>
  • <6,4;Reduction;R1>
  • <4,5;Reduction;R1>
  • <5,7;Oxidation;R1>
  • <7,9;Reduction;R1>
  • <3,4;Oxidation;R1>
  • <7,H;Hydroxylation;R1>
  • <8,H;Hydroxylation;R2>
  • <1,9;Oxidation;R3>
  • <9,8;Reduction;R3>
  • <8,6;Oxidation;R3>
  • <6,4;Reduction;R3>
  • <4,5;Reduction;R3>
  • <5,7;Oxidation;R3>
  • <7,9;Reduction;R3>
  • <3,4;Oxidation;R3>
  • <1,9;Oxidation;R1>
  • <9,8;Reduction;R1>
  • <8,6;Oxidation;R1>
  • <6,4;Reduction;R1>
  • <4,5;Reduction;R1>
  • <5,7;Oxidation;R1>
  • <7,9;Reduction;R1>
  • <3,4;Oxidation;R1>
References
  1. Dong H, Haining RL, Thummel KE, Rettie AE, Nelson SD: Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos. 2000 Dec;28(12):1397-400. [PubMed:11095574 ]
  2. Raucy JL, Lasker JM, Lieber CS, Black M: Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys. 1989 Jun;271(2):270-83. doi: 10.1016/0003-9861(89)90278-6. [PubMed:2729995 ]
  3. Patten CJ, Thomas PE, Guy RL, Lee M, Gonzalez FJ, Guengerich FP, Yang CS: Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem Res Toxicol. 1993 Jul-Aug;6(4):511-8. [PubMed:8374050 ]
  4. Chen W, Koenigs LL, Thompson SJ, Peter RM, Rettie AE, Trager WF, Nelson SD: Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6. Chem Res Toxicol. 1998 Apr;11(4):295-301. doi: 10.1021/tx9701687. [PubMed:9548799 ]
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