Showing CypComp Card for CC01879: Aflatoxin B1 (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:26 UTC
Last Updated2019-10-01 21:40:57 UTC
CypComp IDCC01879
Compound Information
NameAflatoxin B1
Structure ImageOqiqstljslghid wnwijwbnsa n
InChIKeyOQIQSTLJSLGHID-WNWIJWBNSA-N
PubChem ID186907
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <23,H;Oxidation;R1>
  • <23,22;Cleavage;R1>
  • <11,H;Hydroxylation;R2>
  • <17,18;Epoxidation;R3>
  • <14,H;Hydroxylation;R4>
  • <23,H;Oxidation;R1>
  • <23,22;Cleavage;R2>
  • <11,H;Hydroxylation;R3>
  • <14,H;Hydroxylation;R4>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <11,H;Hydroxylation;R1>
  • <17,18;Epoxidation;R2>
References
  1. Gallagher EP, Kunze KL, Stapleton PL, Eaton DL: The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol Appl Pharmacol. 1996 Dec;141(2):595-606. doi: 10.1006/taap.1996.0326. [PubMed:8975785 ]
  2. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY: Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract. Int J Cancer. 2006 Jun 1;118(11):2665-71. doi: 10.1002/ijc.21665. [PubMed:16385575 ]
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