Showing CypComp Card for CC01886: Amiodarone (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:29 UTC
Last Updated2019-10-01 21:40:58 UTC
CypComp IDCC01886
Compound Information
NameAmiodarone
Structure ImageIyiklhrqxlhmjq uhfffaoysa n
InChIKeyIYIKLHRQXLHMJQ-UHFFFAOYSA-N
PubChem ID2157
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <30,27;Cleavage;R1>
  • <30,H;Oxidation;R1>
  • <28,27;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • Not Available
  • Not Available
  • <30,27;Cleavage;R1>
  • <30,H;Oxidation;R1>
  • <28,27;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • <30,27;Cleavage;R1>
  • <30,H;Oxidation;R1>
  • <28,27;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • <30,27;Cleavage;R1>
  • <30,H;Oxidation;R1>
  • <28,27;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • <30,27;Cleavage;R1>
  • <30,H;Oxidation;R1>
  • <28,27;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • Not Available
  • <30,27;Cleavage;R1>
  • <30,H;Oxidation;R1>
  • <28,27;Cleavage;R2>
  • <28,H;Oxidation;R2>
References
  1. Ohyama K, Nakajima M, Nakamura S, Shimada N, Yamazaki H, Yokoi T: A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor. Drug Metab Dispos. 2000 Nov;28(11):1303-10. [PubMed:11038157 ]
  2. Fabre G, Julian B, Saint-Aubert B, Joyeux H, Berger Y: Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions. Drug Metab Dispos. 1993 Nov-Dec;21(6):978-85. [PubMed:7905403 ]
Download FileCC01886.sdf