Showing CypComp Card for CC01888: Antipyrine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:30 UTC
Last Updated2019-10-01 21:40:59 UTC
CypComp IDCC01888
Compound Information
NameAntipyrine
Structure ImageVeqoalnaajbpny uhfffaoysa n
InChIKeyVEQOALNAAJBPNY-UHFFFAOYSA-N
PubChem ID2206
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <7,H;Hydroxylation;R1>
  • <9,H;Hydroxylation;R2>
  • <8,3;Cleavage;R3>
  • <8,H;Oxidation;R3>
  • <7,H;Hydroxylation;R1>
  • <9,H;Hydroxylation;R2>
  • <8,3;Cleavage;R3>
  • <8,H;Oxidation;R3>
  • <7,H;Hydroxylation;R1>
  • <7,H;Hydroxylation;R1>
  • <9,H;Hydroxylation;R2>
  • <8,3;Cleavage;R3>
  • <8,H;Oxidation;R3>
  • <7,H;Hydroxylation;R1>
  • <9,H;Hydroxylation;R2>
  • <8,3;Cleavage;R3>
  • <8,H;Oxidation;R3>
  • Not Available
  • <7,H;Hydroxylation;R1>
  • <8,3;Cleavage;R2>
  • <8,H;Oxidation;R2>
  • <7,H;Hydroxylation;R1>
  • <9,H;Hydroxylation;R2>
  • <8,3;Cleavage;R3>
  • <8,H;Oxidation;R3>
  • <7,H;Hydroxylation;R1>
  • <8,3;Cleavage;R2>
  • <8,H;Oxidation;R2>
References
  1. Engel G, Hofmann U, Heidemann H, Cosme J, Eichelbaum M: Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59(6):613-23. doi: 10.1016/S0009-9236(96)90001-6. [PubMed:8681486 ]
  2. Sharer JE, Wrighton SA: Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. Drug Metab Dispos. 1996 Apr;24(4):487-94. [PubMed:8801065 ]
Download FileCC01888.sdf