CypComp Database: Showing CypComp Card for CC01890: Arachidonic acid (CypBoM Training Set)

Record Information

Version

1.0

Creation Date

2019-07-14 16:35:31 UTC

Last Updated

2019-10-01 21:40:59 UTC

CypComp ID

CC01890

Compound Information

Name

Arachidonic acid

Structure Image

InChIKey

YZXBAPSDXZZRGB-DOFZRALJSA-N

PubChem ID

CypCompound Information

Set

CypBoM Training Set

Bonds of Metabolism (BoMs)

CYP1A2	CYP2A6	CYP2B6	CYP2C8	CYP2C9	CYP2C19	CYP2D6	CYP2E1	CYP3A4
<7,11;EpOxidation;R1> <16,19;EpOxidation;R2> <20,21;EpOxidation;R3> <4,H;Hydroxylation;R4> <6,H;Hydroxylation;R5> <8,H;Hydroxylation;R6> <12,H;Hydroxylation;R7> <15,H;Hydroxylation;R8> <18,H;Hydroxylation;R9>	<6,H;Hydroxylation;R1>	<6,H;Hydroxylation;R1> <7,11;EpOxidation;R2>	<8,H;Hydroxylation;R1> <6,H;Hydroxylation;R2> <7,11;EpOxidation;R3> <16,19;EpOxidation;R4> <12,H;Hydroxylation;R5> <15,H;Hydroxylation;R6> <18,H;Hydroxylation;R7>	<8,H;Hydroxylation;R1> <6,H;Hydroxylation;R2> <7,11;EpOxidation;R3> <16,19;EpOxidation;R4> <12,H;Hydroxylation;R5> <15,H;Hydroxylation;R6> <18,H;Hydroxylation;R7>	<7,11;EpOxidation;R1> <16,19;EpOxidation;R2> <6,H;Hydroxylation;R3>	<6,H;Hydroxylation;R1>	<6,H;Hydroxylation;R1>	<6,H;Hydroxylation;R1> <8,H;Hydroxylation;R2> <12,H;Hydroxylation;R3> <15,H;Hydroxylation;R4> <18,H;Hydroxylation;R5>

References

Rifkind AB, Lee C, Chang TK, Waxman DJ: Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. Arch Biochem Biophys. 1995 Jul 10;320(2):380-9. doi: 10.1016/0003-9861(95)90023-3. [PubMed:7625847 ]
Bylund J, Kunz T, Valmsen K, Oliw EH: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. J Pharmacol Exp Ther. 1998 Jan;284(1):51-60. [PubMed:9435160 ]

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