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Record Information
Version1.0
Creation Date2019-07-14 16:35:31 UTC
Last Updated2019-10-01 21:40:59 UTC
CypComp IDCC01890
Compound Information
NameArachidonic acid
Structure ImageYzxbapsdxzzrgb dofzraljsa n
InChIKeyYZXBAPSDXZZRGB-DOFZRALJSA-N
PubChem ID444899
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <7,11;EpOxidation;R1>
  • <16,19;EpOxidation;R2>
  • <20,21;EpOxidation;R3>
  • <4,H;Hydroxylation;R4>
  • <6,H;Hydroxylation;R5>
  • <8,H;Hydroxylation;R6>
  • <12,H;Hydroxylation;R7>
  • <15,H;Hydroxylation;R8>
  • <18,H;Hydroxylation;R9>
  • <6,H;Hydroxylation;R1>
  • <6,H;Hydroxylation;R1>
  • <7,11;EpOxidation;R2>
  • <8,H;Hydroxylation;R1>
  • <6,H;Hydroxylation;R2>
  • <7,11;EpOxidation;R3>
  • <16,19;EpOxidation;R4>
  • <12,H;Hydroxylation;R5>
  • <15,H;Hydroxylation;R6>
  • <18,H;Hydroxylation;R7>
  • <8,H;Hydroxylation;R1>
  • <6,H;Hydroxylation;R2>
  • <7,11;EpOxidation;R3>
  • <16,19;EpOxidation;R4>
  • <12,H;Hydroxylation;R5>
  • <15,H;Hydroxylation;R6>
  • <18,H;Hydroxylation;R7>
  • <7,11;EpOxidation;R1>
  • <16,19;EpOxidation;R2>
  • <6,H;Hydroxylation;R3>
  • <6,H;Hydroxylation;R1>
  • <6,H;Hydroxylation;R1>
  • <6,H;Hydroxylation;R1>
  • <8,H;Hydroxylation;R2>
  • <12,H;Hydroxylation;R3>
  • <15,H;Hydroxylation;R4>
  • <18,H;Hydroxylation;R5>
References
  1. Rifkind AB, Lee C, Chang TK, Waxman DJ: Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. Arch Biochem Biophys. 1995 Jul 10;320(2):380-9. doi: 10.1016/0003-9861(95)90023-3. [PubMed:7625847 ]
  2. Bylund J, Kunz T, Valmsen K, Oliw EH: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. J Pharmacol Exp Ther. 1998 Jan;284(1):51-60. [PubMed:9435160 ]
Download FileCC01890.sdf