Showing CypComp Card for CC01891: Atomoxetine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:32 UTC
Last Updated2019-10-01 21:40:59 UTC
CypComp IDCC01891
Compound Information
NameAtomoxetine
Structure ImageVhgcdtvcolntbx krwdzbqosa n
InChIKeyVHGCDTVCOLNTBX-KRWDZBQOSA-N
PubChem ID6093336
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <12,H;Hydroxylation;R1>
  • <19,H;Oxidation;R2>
  • <19,18;Cleavage;R2>
  • Not Available
  • <12,H;Hydroxylation;R1>
  • <19,H;Oxidation;R2>
  • <19,18;Cleavage;R2>
  • Not Available
  • <19,18;Cleavage;R1>
  • <19,H;Oxidation;R1>
  • <12,H;Hydroxylation;R1>
  • <19,H;Oxidation;R2>
  • <19,18;Cleavage;R2>
  • <12,H;Hydroxylation;R1>
  • <19,H;Oxidation;R2>
  • <19,18;Cleavage;R2>
  • <15,H;Hydroxylation;R3>
  • <12,H;Hydroxylation;R1>
  • <12,H;Hydroxylation;R1>
  • <19,H;Oxidation;R2>
  • <19,18;Cleavage;R2>
References
  1. Ring BJ, Gillespie JS, Eckstein JA, Wrighton SA: Identification of the human cytochromes P450 responsible for atomoxetine metabolism. Drug Metab Dispos. 2002 Mar;30(3):319-23. doi: 10.1124/dmd.30.3.319. [PubMed:11854152 ]
  2. Sauer JM, Ponsler GD, Mattiuz EL, Long AJ, Witcher JW, Thomasson HR, Desante KA: Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism. Drug Metab Dispos. 2003 Jan;31(1):98-107. doi: 10.1124/dmd.31.1.98. [PubMed:12485958 ]
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