Showing CypComp Card for CC01893: Azelastine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:33 UTC
Last Updated2019-10-01 21:40:59 UTC
CypComp IDCC01893
Compound Information
NameAzelastine
Structure ImageMbuvewmhonzeqd gosisdbhsa n
InChIKeyMBUVEWMHONZEQD-GOSISDBHSA-N
PubChem ID12831280
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <27,23;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <27,23;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • <27,23;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • Not Available
  • <27,23;Cleavage;R1>
  • <27,H;Oxidation;R1>
References
  1. Imai T, Taketani M, Suzu T, Kusube K, Otagiri M: In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine. Drug Metab Dispos. 1999 Aug;27(8):942-6. [PubMed:10421623 ]
  2. Nakajima M, Nakamura S, Tokudome S, Shimada N, Yamazaki H, Yokoi T: Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs. Drug Metab Dispos. 1999 Dec;27(12):1381-91. [PubMed:10570018 ]
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