CypComp Database: Showing CypComp Card for CC01898: BPR0L075 (CypBoM Training Set)

Record Information

Version

1.0

Creation Date

2019-07-14 16:35:35 UTC

Last Updated

2019-10-01 21:41:00 UTC

CypComp ID

CC01898

Compound Information

Name

BPR0L075

Structure Image

InChIKey

UZJVBXKFBQNDTQ-UHFFFAOYSA-N

PubChem ID

CypCompound Information

Set

CypBoM Training Set

Bonds of Metabolism (BoMs)

CYP1A2	CYP2A6	CYP2B6	CYP2C8	CYP2C9	CYP2C19	CYP2D6	CYP2E1	CYP3A4
<5,H;Hydroxylation;R1> <3,H;Hydroxylation;R2> <8,7;Cleavage;R3> <8,H;Oxidation;R3>	Not Available	Not Available	Not Available	<5,H;Hydroxylation;R1> <3,H;Hydroxylation;R2> <8,7;Cleavage;R3> <8,H;Oxidation;R3> <21,20;Cleavage;R4> <21,H;Oxidation;R4> <23,22;Cleavage;R5> <23,H;Oxidation;R5> <25,24;Cleavage;R6> <25,H;Oxidation;R6>	<5,H;Hydroxylation;R1> <3,H;Hydroxylation;R2> <8,7;Cleavage;R3> <8,H;Oxidation;R3> <21,20;Cleavage;R4> <21,H;Oxidation;R4> <23,22;Cleavage;R5> <23,H;Oxidation;R5> <25,24;Cleavage;R6> <25,H;Oxidation;R6>	<5,H;Hydroxylation;R1> <3,H;Hydroxylation;R2> <8,7;Cleavage;R3> <8,H;Oxidation;R3> <23,22;Cleavage;R4> <23,H;Oxidation;R4>	<5,H;Hydroxylation;R1> <3,H;Hydroxylation;R2> <8,7;Cleavage;R3> <8,H;Oxidation;R3> <21,20;Cleavage;R4> <21,H;Oxidation;R4> <23,22;Cleavage;R5> <23,H;Oxidation;R5> <25,24;Cleavage;R6> <25,H;Oxidation;R6>	<5,H;Hydroxylation;R1> <3,H;Hydroxylation;R2> <8,7;Cleavage;R3> <8,H;Oxidation;R3> <21,20;Cleavage;R4> <21,H;Oxidation;R4> <23,22;Cleavage;R5> <23,H;Oxidation;R5> <25,24;Cleavage;R6> <25,H;Oxidation;R6>

References

Yao HT, Wu YS, Chang YW, Hsieh HP, Chen WC, Lan SJ, Chen CT, Chao YS, Chang L, Sun HY, Yeh TK: Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes. Drug Metab Dispos. 2007 Jul;35(7):1042-9. doi: 10.1124/dmd.106.014597. Epub 2007 Apr 2. [PubMed:17403915 ]

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