Showing CypComp Card for CC01905: Carvedilol (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:38 UTC
Last Updated2019-10-01 21:41:02 UTC
CypComp IDCC01905
Compound Information
NameCarvedilol
Structure ImageOghnvejmjsyvrp krwdzbqosa n
InChIKeyOGHNVEJMJSYVRP-KRWDZBQOSA-N
PubChem ID185395
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <11,H;Hydroxylation;R1>
  • <30,27;Cleavage;R2>
  • <30,H;Oxidation;R2>
  • Not Available
  • Not Available
  • Not Available
  • <29,H;Hydroxylation;R1>
  • <28,H;Hydroxylation;R2>
  • <30,27;Cleavage;R3>
  • <30,H;Oxidation;R3>
  • Not Available
  • <29,H;Hydroxylation;R1>
  • <28,H;Hydroxylation;R2>
  • <30,27;Cleavage;R3>
  • <30,H;Oxidation;R3>
  • <29,H;Hydroxylation;R1>
  • <28,H;Hydroxylation;R2>
  • <30,27;Cleavage;R3>
  • <30,H;Oxidation;R3>
  • <29,H;Hydroxylation;R1>
  • <11,H;Hydroxylation;R2>
References
  1. Oldham HG, Clarke SE: In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol. Drug Metab Dispos. 1997 Aug;25(8):970-7. [PubMed:9280405 ]
  2. Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet. 2009;48(12):761-804. doi: 10.2165/11318070-000000000-00000. [PubMed:19902987 ]
Download FileCC01905.sdf