Bonds of Metabolism (BoMs) | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 | - <21,H;Hydroxylation;R1>
- <17,4;Cleavage;R2>
- <17,H;Oxidation;R2>
- <16,4;Cleavage;R3>
- <16,H;Oxidation;R3>
- <2,S;S-Oxidation;R4>
| | | | | | - <21,H;Hydroxylation;R1>
- <17,4;Cleavage;R2>
- <17,H;Oxidation;R2>
- <16,4;Cleavage;R3>
- <16,H;Oxidation;R3>
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References | - Yoshii K, Kobayashi K, Tsumuji M, Tani M, Shimada N, Chiba K: Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes. Life Sci. 2000;67(2):175-84. doi: 10.1016/s0024-3205(00)00613-5. [PubMed:10901285 ]
- Cashman JR, Yang Z, Yang L, Wrighton SA: Stereo- and regioselective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes. Drug Metab Dispos. 1993 May-Jun;21(3):492-501. [PubMed:8100507 ]
- Zanger UM, Schwab M: Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013 Apr;138(1):103-41. doi: 10.1016/j.pharmthera.2012.12.007. Epub 2013 Jan 16. [PubMed:23333322 ]
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