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Record Information
Version1.0
Creation Date2019-07-14 16:35:39 UTC
Last Updated2019-10-01 21:41:02 UTC
CypComp IDCC01907
Compound Information
NameChlorpromazine
Structure ImageZpeimtdsqakgnt uhfffaoysa n
InChIKeyZPEIMTDSQAKGNT-UHFFFAOYSA-N
PubChem ID2726
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <21,H;Hydroxylation;R1>
  • <17,4;Cleavage;R2>
  • <17,H;Oxidation;R2>
  • <16,4;Cleavage;R3>
  • <16,H;Oxidation;R3>
  • <2,S;S-Oxidation;R4>
  • Not Available
  • <2,S;S-Oxidation;R1>
  • Not Available
  • <2,S;S-Oxidation;R1>
  • Not Available
  • <21,H;Hydroxylation;R1>
  • <17,4;Cleavage;R2>
  • <17,H;Oxidation;R2>
  • <16,4;Cleavage;R3>
  • <16,H;Oxidation;R3>
  • Not Available
  • <2,S;S-Oxidation;R1>
References
  1. Yoshii K, Kobayashi K, Tsumuji M, Tani M, Shimada N, Chiba K: Identification of human cytochrome P450 isoforms involved in the 7-hydroxylation of chlorpromazine by human liver microsomes. Life Sci. 2000;67(2):175-84. doi: 10.1016/s0024-3205(00)00613-5. [PubMed:10901285 ]
  2. Cashman JR, Yang Z, Yang L, Wrighton SA: Stereo- and regioselective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes. Drug Metab Dispos. 1993 May-Jun;21(3):492-501. [PubMed:8100507 ]
  3. Zanger UM, Schwab M: Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 2013 Apr;138(1):103-41. doi: 10.1016/j.pharmthera.2012.12.007. Epub 2013 Jan 16. [PubMed:23333322 ]
Download FileCC01907.sdf