Showing CypComp Card for CC01914: Clomipramine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:41 UTC
Last Updated2019-10-01 21:41:03 UTC
CypComp IDCC01914
Compound Information
NameClomipramine
Structure ImageGdligkioyrnhda uhfffaoysa n
InChIKeyGDLIGKIOYRNHDA-UHFFFAOYSA-N
PubChem ID2801
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <21,19;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <20,19;Cleavage;R2>
  • <20,H;Oxidation;R2>
  • <2,H;Hydroxylation;R3>
  • Not Available
  • Not Available
  • <21,19;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <20,19;Cleavage;R2>
  • <20,H;Oxidation;R2>
  • <2,H;Hydroxylation;R1>
  • <21,19;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <20,19;Cleavage;R2>
  • <20,H;Oxidation;R2>
  • <21,19;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <20,19;Cleavage;R2>
  • <20,H;Oxidation;R2>
  • <2,H;Hydroxylation;R3>
  • <11,H;Hydroxylation;R4>
  • Not Available
  • <21,19;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <20,19;Cleavage;R2>
  • <20,H;Oxidation;R2>
References
  1. Nielsen KK, Flinois JP, Beaune P, Brosen K: The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways. J Pharmacol Exp Ther. 1996 Jun;277(3):1659-64. [PubMed:8667235 ]
Download FileCC01914.sdf