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Showing CypComp Card for CC01915: Clopidogrel (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:41 UTC
Last Updated2019-10-01 21:41:03 UTC
CypComp IDCC01915
Compound Information
NameClopidogrel
Structure ImageGktwggqpfaxnfi oahllokosa n
InChIKeyGKTWGGQPFAXNFI-OAHLLOKOSA-N
PubChem ID667556
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <3,H;Oxidation;R1>
  • <3,2;Reduction;R1>
  • <2,1;Oxidation;R1>
  • <1,5;Reduction;R1>
  • Not Available
  • <3,H;Oxidation;R1>
  • <3,2;Reduction;R1>
  • <2,1;Oxidation;R1>
  • <1,5;Reduction;R1>
  • <3,H;Oxidation;R1>
  • <3,2;Reduction;R1>
  • <2,1;Oxidation;R1>
  • <1,5;Reduction;R1>
  • <3,H;Oxidation;R1>
  • <3,2;Reduction;R1>
  • <2,1;Oxidation;R1>
  • <1,5;Reduction;R1>
  • <3,H;Oxidation;R1>
  • <3,2;Reduction;R1>
  • <2,1;Oxidation;R1>
  • <1,5;Reduction;R1>
  • <3,H;Oxidation;R1>
  • <3,2;Reduction;R1>
  • <2,1;Oxidation;R1>
  • <1,5;Reduction;R1>
  • Not Available
  • Not Available
References
  1. Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A: Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos. 2010 Jan;38(1):92-9. doi: 10.1124/dmd.109.029132. [PubMed:19812348 ]
  2. Dansette PM, Libraire J, Bertho G, Mansuy D: Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel. Chem Res Toxicol. 2009 Feb;22(2):369-73. doi: 10.1021/tx8004828. [PubMed:19170597 ]
Download FileCC01915.sdf