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Record Information
Version1.0
Creation Date2019-07-14 16:35:42 UTC
Last Updated2019-10-01 21:41:03 UTC
CypComp IDCC01917
Compound Information
NameClozapine
Structure ImageQzudbnbuxvuhmw uhfffaoysa n
InChIKeyQZUDBNBUXVUHMW-UHFFFAOYSA-N
PubChem ID135398737
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <22,19;Cleavage;R1>
  • <22,H;Oxidation;R1>
  • <19,N;N-Oxidation;R2>
  • Not Available
  • Not Available
  • <22,19;Cleavage;R1>
  • <22,H;Oxidation;R1>
  • <19,N;N-Oxidation;R2>
  • <22,19;Cleavage;R1>
  • <22,H;Oxidation;R1>
  • <22,19;Cleavage;R1>
  • <22,H;Oxidation;R1>
  • <19,N;N-Oxidation;R2>
  • <22,19;Cleavage;R1>
  • <22,H;Oxidation;R1>
  • <19,N;N-Oxidation;R2>
  • <22,19;Cleavage;R1>
  • <22,H;Oxidation;R1>
  • <22,19;Cleavage;R1>
  • <22,H;Oxidation;R1>
  • <19,N;N-Oxidation;R2>
References
  1. Tugnait M, Hawes EM, McKay G, Eichelbaum M, Midha KK: Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine. Chem Biol Interact. 1999 Apr 1;118(2):171-89. [PubMed:10359460 ]
  2. Fang J, Coutts RT, McKenna KF, Baker GB: Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):592-9. [PubMed:9840430 ]
Download FileCC01917.sdf