Bonds of Metabolism (BoMs) | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 | - <10,H;Hydroxylation;R1>
- <6,3;Cleavage;R2>
- <6,H;Oxidation;R2>
- <7,3;Cleavage;R3>
- <7,H;Oxidation;R3>
| | | | | | | | - <10,H;Hydroxylation;R1>
- <6,3;Cleavage;R2>
- <6,H;Oxidation;R2>
- <7,3;Cleavage;R3>
- <7,H;Oxidation;R3>
|
|
---|
References | - Roy P, Yu LJ, Crespi CL, Waxman DJ: Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. [PubMed:10348794 ]
- Bohnenstengel F, Hofmann U, Eichelbaum M, Kroemer HK: Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans. Eur J Clin Pharmacol. 1996;51(3-4):297-301. [PubMed:9010702 ]
|
---|