Showing CypComp Card for CC01949: Flunitrazepam (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:55 UTC
Last Updated2019-10-01 21:41:07 UTC
CypComp IDCC01949
Compound Information
NameFlunitrazepam
Structure ImagePptyjkaxvccbdu uhfffaoysa n
InChIKeyPPTYJKAXVCCBDU-UHFFFAOYSA-N
PubChem ID3380
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <21,11;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <9,H;Hydroxylation;R1>
  • <21,11;Cleavage;R2>
  • <21,H;Oxidation;R2>
  • <21,11;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <21,11;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <21,11;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <21,11;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <21,11;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • Not Available
  • <9,H;Hydroxylation;R1>
  • <21,11;Cleavage;R2>
  • <21,H;Oxidation;R2>
References
  1. Hesse LM, Venkatakrishnan K, von Moltke LL, Shader RI, Greenblatt DJ: CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001 Feb;29(2):133-40. [PubMed:11159802 ]
  2. Gafni I, Busto UE, Tyndale RF, Kaplan HL, Sellers EM: The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo. J Clin Psychopharmacol. 2003 Apr;23(2):169-75. [PubMed:12640218 ]
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