Showing CypComp Card for CC01950: Fluoxetine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:56 UTC
Last Updated2019-10-01 21:41:07 UTC
CypComp IDCC01950
Compound Information
NameFluoxetine
Structure ImageRthcyvbbdhjxiq inizcteosa n
InChIKeyRTHCYVBBDHJXIQ-INIZCTEOSA-N
PubChem ID1548968
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <17,13;Cleavage;R1>
  • <17,H;Oxidation;R1>
  • <1,3;Cleavage;R1>
  • <1,H;Oxidation;R1>
  • <17,13;Cleavage;R2>
  • <17,H;Oxidation;R2>
  • <17,13;Cleavage;R1>
  • <17,H;Oxidation;R1>
  • Not Available
  • <1,3;Cleavage;R1>
  • <1,H;Oxidation;R1>
  • <17,13;Cleavage;R2>
  • <17,H;Oxidation;R2>
References
  1. Brown CM, Reisfeld B, Mayeno AN: Cytochromes P450: a structure-based summary of biotransformations using representative substrates. Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742. [PubMed:18259985 ]
  2. Ring BJ, Eckstein JA, Gillespie JS, Binkley SN, VandenBranden M, Wrighton SA: Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine. J Pharmacol Exp Ther. 2001 Jun;297(3):1044-50. [PubMed:11356927 ]
  3. Margolis JM, O'Donnell JP, Mankowski DC, Ekins S, Obach RS: (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91. [PubMed:10997938 ]
Download FileCC01950.sdf