Showing CypComp Card for CC01951: Flutamide (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:35:56 UTC
Last Updated2019-10-01 21:41:07 UTC
CypComp IDCC01951
Compound Information
NameFlutamide
Structure ImageMkxkfyhwdhiyrv uhfffaoysa n
InChIKeyMKXKFYHWDHIYRV-UHFFFAOYSA-N
PubChem ID3397
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <9,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • Not Available
  • <9,H;Hydroxylation;R1>
  • <9,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • Not Available
References
  1. Goda R, Nagai D, Akiyama Y, Nishikawa K, Ikemoto I, Aizawa Y, Nagata K, Yamazoe Y: Detection of a new N-oxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl)phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients. Drug Metab Dispos. 2006 May;34(5):828-35. doi: 10.1124/dmd.105.008623. Epub 2006 Feb 28. [PubMed:16507648 ]
  2. Shet MS, McPhaul M, Fisher CW, Stallings NR, Estabrook RW: Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2. Drug Metab Dispos. 1997 Nov;25(11):1298-303. [PubMed:9351907 ]
  3. Maw HH, Zeng X, Campbell S, Taub ME, Teitelbaum AM: N-Methylation of BI 187004 by Thiol S-Methyltransferase. Drug Metab Dispos. 2018 Jun;46(6):770-778. doi: 10.1124/dmd.117.079764. Epub 2018 Mar 7. [PubMed:29514826 ]
Download FileCC01951.sdf