Showing CypComp Card for CC01964: Imipramine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:01 UTC
Last Updated2019-10-01 21:41:08 UTC
CypComp IDCC01964
Compound Information
NameImipramine
Structure ImageBcgwqeupmdmjnv uhfffaoysa n
InChIKeyBCGWQEUPMDMJNV-UHFFFAOYSA-N
PubChem ID3696
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <12,7;Cleavage;R1>
  • <12,H;Oxidation;R1>
  • <13,7;Cleavage;R2>
  • <13,H;Oxidation;R2>
  • <20,H;Hydroxylation;R3>
  • <21,H;Hydroxylation;R4>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <12,7;Cleavage;R1>
  • <12,H;Oxidation;R1>
  • <13,7;Cleavage;R2>
  • <13,H;Oxidation;R2>
  • <20,H;Hydroxylation;R3>
  • <21,H;Hydroxylation;R4>
  • <12,7;Cleavage;R1>
  • <12,H;Oxidation;R1>
  • <13,7;Cleavage;R2>
  • <13,H;Oxidation;R2>
  • <20,H;Hydroxylation;R3>
  • <21,H;Hydroxylation;R4>
  • Not Available
  • Not Available
References
  1. Koyama E, Chiba K, Tani M, Ishizaki T: Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. [PubMed:9190854 ]
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