Showing CypComp Card for CC01969: Lidocaine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:03 UTC
Last Updated2019-10-01 21:41:09 UTC
CypComp IDCC01969
Compound Information
NameLidocaine
Structure ImageNnjvilvzkwqkpm uhfffaoysa n
InChIKeyNNJVILVZKWQKPM-UHFFFAOYSA-N
PubChem ID3676
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <11,10;Cleavage;R1>
  • <11,H;Oxidation;R1>
  • <12,10;Cleavage;R2>
  • <12,H;Oxidation;R2>
  • <2,H;Hydroxylation;R3>
  • <4,H;Hydroxylation;R4>
  • Not Available
  • <11,10;Cleavage;R1>
  • <11,H;Oxidation;R1>
  • <12,10;Cleavage;R2>
  • <12,H;Oxidation;R2>
  • Not Available
  • Not Available
  • Not Available
  • <2,H;Hydroxylation;R1>
  • <4,H;Hydroxylation;R2>
  • Not Available
  • <11,10;Cleavage;R1>
  • <11,H;Oxidation;R1>
  • <12,10;Cleavage;R2>
  • <12,H;Oxidation;R2>
  • <2,H;Hydroxylation;R3>
  • <4,H;Hydroxylation;R4>
References
  1. Imaoka S, Yamada T, Hiroi T, Hayashi K, Sakaki T, Yabusaki Y, Funae Y: Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat. Biochem Pharmacol. 1996 Apr 26;51(8):1041-50. doi: 10.1016/0006-2952(96)00052-4. [PubMed:8866826 ]
  2. Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT: Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. [PubMed:10901707 ]
  3. Imaoka S, Enomoto K, Oda Y, Asada A, Fujimori M, Shimada T, Fujita S, Guengerich FP, Funae Y: Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s. J Pharmacol Exp Ther. 1990 Dec;255(3):1385-91. [PubMed:2262908 ]
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