Showing CypComp Card for CC01970: Linoleic acid (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:03 UTC
Last Updated2019-10-01 21:41:09 UTC
CypComp IDCC01970
Compound Information
NameLinoleic acid
Structure ImageOyhqolukzrvurq avqmffatsa n
InChIKeyOYHQOLUKZRVURQ-AVQMFFATSA-N
PubChem ID5282457
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <4,H;Hydroxylation;R1>
  • <4,6;Reduction;R1>
  • <6,8;Dehydrogenation;R1>
  • <12,H;Hydroxylation;R2>
  • <12,10;Reduction;R2>
  • <10,9;Dehydrogenation;R2>
  • <8,H;Hydroxylation;R3>
  • <19,H;Hydroxylation;R4>
  • <20,H;Hydroxylation;R5>
  • Not Available
  • Not Available
  • <8,H;Hydroxylation;R1>
  • <4,H;Hydroxylation;R1>
  • <4,6;Reduction;R1>
  • <6,8;Dehydrogenation;R1>
  • <12,H;Hydroxylation;R2>
  • <12,10;Reduction;R2>
  • <10,9;Dehydrogenation;R2>
  • <8,H;Hydroxylation;R3>
  • <19,H;Hydroxylation;R4>
  • <20,H;Hydroxylation;R5>
  • <4,6;EpOxidation;R6>
  • <10,12;EpOxidation;R7>
  • <4,H;Hydroxylation;R1>
  • <4,6;Reduction;R1>
  • <6,8;Dehydrogenation;R1>
  • <12,H;Hydroxylation;R2>
  • <12,10;Reduction;R2>
  • <10,9;Dehydrogenation;R2>
  • <8,H;Hydroxylation;R3>
  • <19,H;Hydroxylation;R4>
  • <20,H;Hydroxylation;R5>
  • <4,6;EpOxidation;R6>
  • <10,12;EpOxidation;R7>
  • Not Available
  • Not Available
  • <4,H;Hydroxylation;R1>
  • <4,6;Reduction;R1>
  • <6,8;Dehydrogenation;R1>
  • <12,H;Hydroxylation;R2>
  • <12,10;Reduction;R2>
  • <10,9;Dehydrogenation;R2>
  • <8,H;Hydroxylation;R3>
  • <19,H;Hydroxylation;R4>
  • <20,H;Hydroxylation;R5>
References
  1. Adas F, Salaun JP, Berthou F, Picart D, Simon B, Amet Y: Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11. J Lipid Res. 1999 Nov;40(11):1990-7. [PubMed:10553002 ]
  2. Bylund J, Kunz T, Valmsen K, Oliw EH: Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. J Pharmacol Exp Ther. 1998 Jan;284(1):51-60. [PubMed:9435160 ]
  3. Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. [PubMed:19754423 ]
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