Showing CypComp Card for CC01980: Mephenytoin (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:07 UTC
Last Updated2019-10-01 21:41:10 UTC
CypComp IDCC01980
Compound Information
NameMephenytoin
Structure ImageGmhkmtdvrcwudx gfccvegcsa n
InChIKeyGMHKMTDVRCWUDX-GFCCVEGCSA-N
PubChem ID119127
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • <13,12;Cleavage;R1>
  • <13,H;Oxidation;R1>
  • Not Available
  • <13,12;Cleavage;R1>
  • <13,H;Oxidation;R1>
  • <7,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • Not Available
References
  1. Goldstein JA, Faletto MB, Romkes-Sparks M, Sullivan T, Kitareewan S, Raucy JL, Lasker JM, Ghanayem BI: Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. Biochemistry. 1994 Feb 22;33(7):1743-52. doi: 10.1021/bi00173a017. [PubMed:8110777 ]
  2. Walsky RL, Obach RS: Validated assays for human cytochrome P450 activities. Drug Metab Dispos. 2004 Jun;32(6):647-60. doi: 10.1124/dmd.32.6.647. [PubMed:15155557 ]
  3. Coller JK, Somogyi AA, Bochner F: Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Br J Clin Pharmacol. 1999 Aug;48(2):158-67. doi: 10.1046/j.1365-2125.1999.00005.x. [PubMed:10417492 ]
  4. Ko JW, Desta Z, Flockhart DA: Human N-demethylation of (S)-mephenytoin by cytochrome P450s 2C9 and 2B6. Drug Metab Dispos. 1998 Aug;26(8):775-8. [PubMed:9698292 ]
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