Showing CypComp Card for CC01985: Methoxychlor-mono-OH (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:08 UTC
Last Updated2019-10-01 21:41:11 UTC
CypComp IDCC01985
Compound Information
NameMethoxychlor-mono-OH
Structure ImageBuzuqnxgkrjijt cqszacivsa n
InChIKeyBUZUQNXGKRJIJT-CQSZACIVSA-N
PubChem ID13590211
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <20,18;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <14,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <20,18;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <14,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <20,18;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <14,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <20,18;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <14,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <20,18;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <20,18;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <14,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <20,18;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <14,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <20,18;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <14,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <14,H;Hydroxylation;R1>
  • <15,H;Hydroxylation;R2>
References
  1. Hu Y, Kupfer D: Metabolism of the endocrine disruptor pesticide-methoxychlor by human P450s: pathways involving a novel catechol metabolite. Drug Metab Dispos. 2002 Sep;30(9):1035-42. doi: 10.1124/dmd.30.9.1035. [PubMed:12167570 ]
  2. Stresser DM, Kupfer D: Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor. Biochemistry. 1997 Feb 25;36(8):2203-10. doi: 10.1021/bi962129k. [PubMed:9047321 ]
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