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Showing CypComp Card for CC01996: Nicardipine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:12 UTC
Last Updated2019-10-01 21:41:13 UTC
CypComp IDCC01996
Compound Information
NameNicardipine
Structure ImageZbbhbtpttswhba xmmpixpasa n
InChIKeyZBBHBTPTTSWHBA-XMMPIXPASA-N
PubChem ID6603948
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • <28,27;Cleavage;R1>
  • <28,H;Oxidation;R1>
  • <13,H;Oxidation;R2>
  • <13,9;Rearrangement;R2>
  • <9,4;Rearrangement;R2>
  • <4,1;Rearrangement;R2>
  • <1,3;Rearrangement;R2>
  • <3,7;Rearrangement;R2>
  • <7,13;Rearrangement;R2>
  • <1,H;Oxidation;R2>
  • Not Available
  • Not Available
  • <28,27;Cleavage;R1>
  • <28,H;Oxidation;R1>
  • Not Available
  • <28,27;Cleavage;R1>
  • <28,H;Oxidation;R1>
  • <13,H;Oxidation;R2>
  • <13,9;Rearrangement;R2>
  • <9,4;Rearrangement;R2>
  • <4,1;Rearrangement;R2>
  • <1,3;Rearrangement;R2>
  • <3,7;Rearrangement;R2>
  • <7,13;Rearrangement;R2>
  • <1,H;Oxidation;R2>
References
  1. Nakamura K, Ariyoshi N, Iwatsubo T, Fukunaga Y, Higuchi S, Itoh K, Shimada N, Nagashima K, Yokoi T, Yamamoto K, Horiuchi R, Kamataki T: Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes. Biol Pharm Bull. 2005 May;28(5):882-5. [PubMed:15863898 ]
Download FileCC01996.sdf