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Record Information
Version1.0
Creation Date2019-07-14 16:36:14 UTC
Last Updated2019-10-01 21:41:13 UTC
CypComp IDCC02000
Compound Information
NameNortriptyline
Structure ImagePhvgltmqbufiqq uhfffaoysa n
InChIKeyPHVGLTMQBUFIQQ-UHFFFAOYSA-N
PubChem ID4543
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <20,19;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <20,19;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <20,19;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <13,H;Hydroxylation;R2>
  • <10,H;Hydroxylation;R3>
  • Not Available
  • <13,H;Hydroxylation;R1>
  • <10,H;Hydroxylation;R2>
References
  1. Breyer-Pfaff U: The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man. Drug Metab Rev. 2004 Oct;36(3-4):723-46. doi: 10.1081/DMR-200033482. [PubMed:15554244 ]
  2. Finch CK, Chrisman CR, Baciewicz AM, Self TH: Rifampin and rifabutin drug interactions: an update. Arch Intern Med. 2002 May 13;162(9):985-92. [PubMed:11996607 ]
Download FileCC02000.sdf