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Showing CypComp Card for CC02004: Olanzapine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:15 UTC
Last Updated2019-10-01 21:41:14 UTC
CypComp IDCC02004
Compound Information
NameOlanzapine
Structure ImageKvwdhtxuzhcgio uhfffaoysa n
InChIKeyKVWDHTXUZHCGIO-UHFFFAOYSA-N
PubChem ID135398745
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <15,H;Hydroxylation;R1>
  • <19,N;N-Oxidation;R2>
  • <20,19;Cleavage;R3>
  • <20,H;Oxidation;R3>
  • <5,H;Hydroxylation;R4>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <15,H;Hydroxylation;R1>
  • <19,N;N-Oxidation;R2>
  • <20,19;Cleavage;R3>
  • <20,H;Oxidation;R3>
  • <5,H;Hydroxylation;R4>
  • Not Available
  • <15,H;Hydroxylation;R1>
  • <19,N;N-Oxidation;R2>
  • <20,19;Cleavage;R3>
  • <20,H;Oxidation;R3>
References
  1. Ring BJ, Catlow J, Lindsay TJ, Gillespie T, Roskos LK, Cerimele BJ, Swanson SP, Hamman MA, Wrighton SA: Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine. J Pharmacol Exp Ther. 1996 Feb;276(2):658-66. [PubMed:8632334 ]
Download FileCC02004.sdf