You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on CypComp Database.
Record Information
Version1.0
Creation Date2019-07-14 16:36:19 UTC
Last Updated2019-10-01 21:41:15 UTC
CypComp IDCC02015
Compound Information
NamePerphenazine
Structure ImageRgcvknlcsqqdep uhfffaoysa n
InChIKeyRGCVKNLCSQQDEP-UHFFFAOYSA-N
PubChem ID4748
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • Not Available
  • Not Available
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • <10,S;S-Oxidation;R2>
  • <18,H;Hydroxylation;R3>
  • Not Available
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
References
  1. Olesen OV, Linnet K: Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. Br J Clin Pharmacol. 2000 Dec;50(6):563-71. doi: 10.1046/j.1365-2125.2000.00298.x. [PubMed:11136295 ]
  2. Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet. 2009;48(12):761-804. doi: 10.2165/11318070-000000000-00000. [PubMed:19902987 ]
Download FileCC02015.sdf