Showing CypComp Card for CC02022: Progesterone (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:22 UTC
Last Updated2019-10-01 21:41:16 UTC
CypComp IDCC02022
Compound Information
NameProgesterone
Structure ImageRjkfovlporlftn lekssakusa n
InChIKeyRJKFOVLPORLFTN-LEKSSAKUSA-N
PubChem ID5994
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <8,H;Hydroxylation;R1>
  • <8,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • <8,H;Hydroxylation;R1>
  • <19,H;Hydroxylation;R2>
  • <22,H;Hydroxylation;R3>
  • <8,H;Hydroxylation;R1>
  • <19,H;Hydroxylation;R2>
  • <22,H;Hydroxylation;R3>
  • <18,H;Hydroxylation;R4>
  • <4,H;Hydroxylation;R5>
  • <8,H;Hydroxylation;R1>
  • <19,H;Hydroxylation;R2>
  • Not Available
  • <8,H;Hydroxylation;R1>
  • <19,H;Hydroxylation;R2>
  • <22,H;Hydroxylation;R3>
  • <4,H;Hydroxylation;R4>
References
  1. Niwa T, Yabusaki Y, Honma K, Matsuo N, Tatsuta K, Ishibashi F, Katagiri M: Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47. doi: 10.1080/004982598239290. [PubMed:9667077 ]
  2. Yamazaki H, Shimada T: Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9. doi: 10.1006/abbi.1997.0302. [PubMed:9328296 ]
Download FileCC02022.sdf