Showing CypComp Card for CC02024: Propafenone (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:23 UTC
Last Updated2019-10-01 21:41:16 UTC
CypComp IDCC02024
Compound Information
NamePropafenone
Structure ImageJwhauxfosrperk sfhvurjksa n
InChIKeyJWHAUXFOSRPERK-SFHVURJKSA-N
PubChem ID184820
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <23,21;Cleavage;R1>
  • <23,H;Oxidation;R1>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <12,H;Hydroxylation;R1>
  • Not Available
  • <23,21;Cleavage;R1>
  • <23,H;Oxidation;R1>
References
  1. Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK: Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites. Mol Pharmacol. 1993 Jan;43(1):120-6. [PubMed:8423765 ]
  2. Kroemer HK, Fischer C, Meese CO, Eichelbaum M: Enantiomer/enantiomer interaction of (S)- and (R)-propafenone for cytochrome P450IID6-catalyzed 5-hydroxylation: in vitro evaluation of the mechanism. Mol Pharmacol. 1991 Jul;40(1):135-42. [PubMed:1857335 ]
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